Skin Growth Factors And Cell Renewal



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WHITE PAPER - Skin Growth Factors (click for full text)

White Paper discussing naturally occurring growth factor proteins in the human body. These proteins have been shown to be key players in the cell growth and differentiation process. Skin Authority uses the term Skin Growth Factors to refer to the growth factor technology as applied in its cosmetic formulations. SGF-4 Technology is a trademark of Skin Authority.

In the scientific community, understanding the way that cells grow, survive, and reproduce in the human body is very important to unlocking the keys to many diseases which result from abnormal cell development such as physical deformities, senile dementia, slow wound healing, and tumors. HGF is an acronym for Human Growth Factors, which are naturally occurring proteins in the human body. These proteins have been shown to be key players in the cell growth and differentiation process. Understanding how HGF works has not only proven to be directly related to understanding how to resolve many cell developmental diseases, but it also has direct application to helping someone obtain a more youthful and vibrant look without expensive plastic surgery or Botox* Cosmetic.

Scientists Stanley Cohen and Rita Levi-Montalcini discovered one such growth factor, EGF (Epidermal Growth Factor). They were awarded a Nobel Prize in Medicine in 1986 for their work in understanding the role of EGF in cell biology. Their research laid the groundwork for current clinical applications of EGF in helping skin conditions and reversing the signs of aging in humans. To put it simply, EGF is known to considerably increase skin cell regeneration. In studies, it has been shown that EGF significantly helps in the healing of wounds on the cornea of the eye and on the skin. EGF also helps in the growth and regeneration of many different cells in the body, including fibroblasts, liver, vascular, thyroid, ovary, and pituitary gland cells.

Clinical trials since 1986 have expanded our knowledge of HGF to include not only EGF, but other major human growth factors as well (TGF-b(1-3), PDFG, GM-CSF and Interleukins). We have since discovered that local application of Human Growth Factors can be used in areas of the human body damaged in surgery, burns, wounds, or accidents. Research has indicated that HGF, when applied to wounds or burns, increased the rate at which the wound or burn healed. HGF helped to facilitate changes at the cellular level to revert the damaged cells to a younger state, healing the damaged skin in the process. Cosmetic patents of early HGF technology were first issued in 1994.

Thus, the next question became, can HGF be used to reverse the cell aging process? The answer proved to be a resounding yes. HGF research was then further applied to the topical skin care industry, where HGF is now proving to regenerate aging skin. In 2001, two independent double blind studies presented to the Society of Investigative Dermatology in Washington, D. C. had tested topical creams containing natural and bioengineered HGF. Both were found to produce better results on skin than expensive plastic surgery or Botox*, when used twice daily for 4-6 weeks. Skin cells that have aged absorb the HGF nutrients and transform back into vibrant young skin cells, giving the user a more youthful look, especially in their facial area. Each study showed significant increases in production of collagen, hyaluronic acid, elastin, fibroblasts, and epidermal thickness. In the early 2000s there were stumbling blocks to making the technology widely available: costs of bioengineering HGF derived from human sources; stabilizing shelf life of naturally sourced HGF; and purifying the HGF to smell and feel pleasing to the nose as well as the skin.

In 2006, Skin Authority began discussions with researchers at a company harvesting HGF as part of a process to produce new skin tissue used for treatment of severe burns, deep wounds and skin ulcerations. The goal was to collaborate to develop Skin Authority topical applications utilizing HGF to reduce wrinkles or repair photo damaged skin without the side effects of common anti aging options such as tretinoin, collagen, Retin A, etc. As a result of this collaboration, the Skin Authority Skin Growth Factor technology (SGF-4 Technology™) was born. Inspired by the wrinkle reversing benefits of four key Skin Growth Factors, Skin Authority developed an exclusive serum which dramatically reduces the look of wrinkles in just 4 weeks(1). Skin Authority Wrinkle Reversing Serum with SGF-4 Technology™ revitalizes aging cells with vital human sourced nutrients to make visibly younger skin a reality. Results of the study include:

• 94% saw overall improvement in skin
• 85% saw improvement in skin texture/smoothness
• 79% felt an increase in skin firmness and elasticity
• 87% saw reduction in fine lines and wrinkles

SGF-4 Technology™ draws from the power of 4 remarkable growth factors:

TGF-b(1-3) (Transforming Growth Factor Beta) to help stimulate collagen, to help inhibit cellular breakdown, and to help enable cells to locate nutrients.

PDFG (Platelet Derived Growth Factor) to help activate wound healing fostering new skin growth, to help reduce scar tissue, and to help form stronger blood vessels.

GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) to help restore blood cell response to the breakdown of skin structure, to help counteract infection (e.g., acne), to help even-out discolored appearance (e.g., hyperpigmentation), to help reduce inflammation (e.g., Rosacea), and to help brighten dull appearance.

Interleukins (IL3, IL6-8) to help enhance natural cell defense, to help balance cell nutrients, and to help improve anti-inflammatory response.

Wrinkle Reversing Serum can produce brilliant line and wrinkle reducing results used alone or combine with Skin Authority resurfacing products as a multi-step approach to eliminating advanced discoloration and photo aging.

REFERENCES
Stanley Cohen and Rita Levi-Montalcini, “For Their Discoveries of Growth Factors,” 1986 Nobel Prize.
Results of Double Of Blind Study Presented To The Society of Investigative Dermatology in Washington, D. C, May 21, 2001.
“New Developments in Growth Factors”, Gail K Naughton, PhD., published by the Society of Plastic Surgical Skin Care Specialists.

*Botox Cosmetic is a trademark of Allergan. SGF-4 Technology is a trademark of Skin Authority, LLC.

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